BDBM50607680 CHEMBL5218702::US20240239774, Example 77

SMILES CC1(O)CCN(CCOc2ccccc2Cc2cn(nc2-c2cc(Cl)nc(N)n2)C(F)F)CC1

InChI Key InChIKey=OTJPAEGXEIKXMR-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50607680   

TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607680(CHEMBL5218702 | US20240239774, Example 77)
Affinity DataIC50: 4nMAssay Description:Inhibition of human ADCY10 assessed as cAMP accumulation preincubated for 15 mins followed by substrate addition using alpha-32P labelled ATP as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Rat)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607680(CHEMBL5218702 | US20240239774, Example 77)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607680(CHEMBL5218702 | US20240239774, Example 77)
Affinity DataKd:  3.60nMAssay Description:Binding affinity to human recombinant His-tagged ADCY10 assessed as dissociation constant and measured for 600 sec by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetAdenylate cyclase type 10(Human)
Tri-Institutional Institutional Therapeutics Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50607680(CHEMBL5218702 | US20240239774, Example 77)
Affinity DataIC50: 2.40nMAssay Description:Assays for sAC activity using purified protein were performed in 100 ul reactions containing 4 mM MgCl2, 2 mM CaCl2, 1 mM ATP, 40 mM NaHCO3, 50 mM Tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2024
Entry Details
Go to US Patent