BDBM693816 (1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-yl)-1-methyl-2-oxo-1,6-naphthyridin-7-yl]cyclopropane-1-carboxamide ::US20240287062, Compound 28

SMILES Cc1c(F)cncc1-c1cc2cnc(NC(=O)[C@@H]3C[C@@H]3F)cc2n(C)c1=O

InChI Key InChIKey=ZTVVCFPBVBLXET-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 693816   

TargetV299L(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 0.190nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetY253F(Human)
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 0.530nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetABL1(Human)
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 1.20nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetH396P(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 1.40nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetE255V(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 1.40nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetQ252H(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 1.70nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetE255K(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 3.40nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetY253H(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 3.60nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetG250E(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 3.70nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetM351T(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 4.5nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetF317L(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 107nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetF317I(Homo sapiens (Human))
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 114nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent

TargetT351I(Human)
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US Patent
LigandPNGBDBM693816((1S,2S)-2-fluoro-N-[3-(5-fluoro-4-methylpyridin-3-...)
Affinity DataIC50: 500nMAssay Description:Kinase activity of ABL1 was measured using the ADP-Glo system (Promega), which measures formation of ADP using a luminescence-based method. Compounds...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/12/2024
Entry Details
US Patent