BDBM8589 (3-Pyridylmethylene)indane 7b::3-{[(1Z)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]methyl}pyridine

SMILES Clc1ccc2\C(CCc2c1)=C/c1cccnc1

InChI Key InChIKey=GQENGHZHJWXFLG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8589   

TargetCytochrome P450 11B2, mitochondrial(Human)
Saarland University

LigandPNGBDBM8589(3-{[(1Z)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 73nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Saarland University

LigandPNGBDBM8589(3-{[(1Z)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 270nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by monitoring the conversion of deoxycorticosterone to corticosterone in the presence of inhibitor compounds. The pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed
TargetAromatase(Human)
University of Calcutta

Curated by ChEMBL
LigandPNGBDBM8589(3-{[(1Z)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of aromataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetAromatase(Human)
University of Calcutta

Curated by ChEMBL
LigandPNGBDBM8589(3-{[(1Z)-5-chloro-2,3-dihydro-1H-inden-1-ylidene]m...)
Affinity DataIC50: 4.05E+3nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta-3H] Androstenedione during aromatization. After incubation, the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2006
Entry Details Article
PubMed