BDBM8794 1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::Pyrazolo[3,4-d]pyrimidine 2

SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=RLVCBYBGVBOVFV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 8794   

TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 35nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 5.32E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 750nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Nantong University

Curated by ChEMBL
LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Nantong University

Curated by ChEMBL
LigandPNGBDBM8794(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-(4-phen...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of HCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed