BDBM8795 1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phenylamino)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine::Pyrazolo[3,4-d]pyrimidine 3

SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1nc(-c2ccc(Nc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=ZTIRNZHAFJWDRP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8795   

TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

LigandPNGBDBM8795(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phe...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

LigandPNGBDBM8795(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phe...)
Affinity DataIC50: 65nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

LigandPNGBDBM8795(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phe...)
Affinity DataIC50: 3.81E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

LigandPNGBDBM8795(1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-3-[4-(phe...)
Affinity DataIC50: 606nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed