BDBM8797 CHEMBL297363::N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)benzamide::Pyrazolo[3,4-d]pyrimidine 5

SMILES COc1cc(ccc1NC(=O)c1ccccc1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12

InChI Key InChIKey=OKRHYXZXYNXSAO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 8797   

TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 93nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 93nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 189nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 189nMAssay Description:Inhibition of Src protein tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 4.68E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 4.68E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8797(N-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 5.00E+4nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed