BDBM163623 SR-3206::US10807944, Compound RLS2-126::US10870618, Compound 1a::US11731934, Compound RLS2-126
SMILES CCCCNNC(=O)c1ccc(OC)cc1
InChI Key InChIKey=RFMNSSZOADXOBU-UHFFFAOYSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 163623
TargetHistone deacetylase 1/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine
University of Florida College of Medicine
Affinity DataIC50: 1.91E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
TargetHistone deacetylase 2/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine
University of Florida College of Medicine
Affinity DataIC50: 2.52E+3nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-498](Human)
University of Florida College of Medicine
University of Florida College of Medicine
Affinity DataIC50: 430nMAssay Description:Purified HDAC1, HDAC2, and HDAC3 (in complex with the deacetylase activation domain of the human NCOR2 (amino acids 395 498)) were obtained from BPS ...More data for this Ligand-Target Pair
Affinity DataIC50: 157nMAssay Description:Recombinant HDACs 1, 2, and 3 (BPS Biosciences) were diluted to a concentration of 1 nM in HDAC buffer. 10 uL of this solution was added in 96-well f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of HDAC2 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of HDAC3 (unknown origin) using acetylated 7-amino-4-methylcoumarin (AMC) as peptide substrate measured after 20 mins by fluorescence base...More data for this Ligand-Target Pair
Affinity DataIC50: 157nMAssay Description:Allosteric inhibition of C-terminal His-tagged recombinant human HDAC3 expressed in Sf9 cells pre-incubated for 2 hrs before acetylated lysine-aminom...More data for this Ligand-Target Pair
Affinity DataIC50: 727nMAssay Description:Allosteric inhibition of HDAC3 in HEK293 cell lysates pre-incubated for 2 hrs before acetylated lysine-aminomethyl coumarin-BOC addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+3nMAssay Description:These SAR data indicate that a tripartite structure of this scaffold with a central C(O) NH NH unit flanked by a phenyl group and a short aliphatic c...More data for this Ligand-Target Pair