BDBM648368 acsmedchemlett.2c00502 OICR 7859A, 21

SMILES c1cncc(c1NC(=O)Cn2ccc3c2N=C(NC3=O)N)Cl

InChI Key InChIKey=MOOOFDHGGWGWDP-UHFFFAOYSA-N

Data  1 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 648368   

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648368(acsmedchemlett.2c00502 OICR 7859A, 21)
Affinity DataIC50: 1.60E+4nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648368(acsmedchemlett.2c00502 OICR 7859A, 21)
Affinity DataKd:  1.00E+4nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandPNGBDBM648368(acsmedchemlett.2c00502 OICR 7859A, 21)
Affinity DataKd:  1.10E+4nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMedPDB3D3D Structure (crystal)