BDBM8793 7-[4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine::CHEMBL45177::Pyrrolo[2,3-d]pyrimidine 1::US11963960, Example 1

SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=FDVSOQRNTAPCHB-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 8793   

TargetTyrosine-protein kinase Lyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 430nMAssay Description:Inhibition of human p56 Lyn tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged LCK (62 to 509 residues) (unknown origin) expressed in Sf9 insect cells at 10 uM using poly (Glu, Tyr) 4:1 as substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 9nMAssay Description:Inhibition of Src kinase (unknown origin) phosphorylation at Tyr416/419 residues incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Flash Therapeutics

US Patent
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 3.30nMAssay Description:HCK kinase reaction (10 μL) containing 4 nM N-terminally GST-tagged HCK (75-526), purified from insect expression system, 5 μM Control AMC ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Fyn(Human)
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of Fyn (unknown origin) using Src-family kinase bisamide rhodamine 110 peptide substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Riken Center For Life Science Technologies

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human C-terminal FLT3 ITD mutant (571 to 993 residues) after 90 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Flash Therapeutics

US Patent
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human HCK SH3-SH2-KD (75 to 526 residues) after 20 mins by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Flash Therapeutics

US Patent
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human HCK (81 to 526 residues) expressed in Sf9 insect cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Flash Therapeutics

US Patent
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 0.427nMAssay Description:Inhibition of HCK (75 to 526 residues) (unknown origin) expressed in Sf9 insect cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 1.07E+4nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 15nMpH: 7.4 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 4.27E+3nMAssay Description:Inhibition of human Csk tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Indo-Soviet Friendship College of Pharmacy (Isfcp)

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of human p55 Fyn tyrosine kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 370nMAssay Description:Inhibition of human B lymphoid tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human p56 Lck tyrosine kinase (lck64-509)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of TIE-2 kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 250nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 1.19E+3nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Yangtze University

Curated by ChEMBL
LigandPNGBDBM8793(CHEMBL45177 | 7-[4-(4-methylpiperazin-1-yl)cyclohe...)
Affinity DataIC50: 42nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2006
Entry Details Article
PubMed