Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 2600
LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22467(5-methyl-5-propyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22472(5,5-diethyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylam...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22466(5-ethyl-5-methyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3...)
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22471(2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en...)
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22474(2-(adamantan-1-ylamino)-5,5-diethyl-4,5-dihydro-1,...)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22468(2-(adamantan-1-ylamino)-5-ethyl-5-methyl-4,5-dihyd...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22469(2-(adamantan-1-ylamino)-5-methyl-5-propyl-4,5-dihy...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22463(2-{bicyclo[2.2.1]heptan-1-ylamino}-5-methyl-5-prop...)
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22470(2-(cyclooctylamino)-5,5-diethyl-4,5-dihydro-1,3-th...)
Affinity DataKi:  26nM ΔG°:  -42.9kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22459(2-(cyclooctylamino)-5-methyl-5-propyl-4,5-dihydro-...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM22475(2-(adamantan-1-ylamino)-1-thia-3-azaspiro[4.4]non-...)
Affinity DataKi:  28nM ΔG°:  -42.7kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22457(2-(cycloheptylamino)-5-methyl-5-propyl-4,5-dihydro...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22455(2-[(cyclohexylmethyl)amino]-5-methyl-5-propyl-4,5-...)
Affinity DataKi:  34nM ΔG°:  -42.2kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22461(5-methyl-5-propyl-2-[(2,2,3,3-tetramethylcycloprop...)
Affinity DataKi:  38nM ΔG°:  -41.9kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22458(2-(cyclooctylamino)-5-ethyl-5-methyl-4,5-dihydro-1...)
Affinity DataKi:  47nM ΔG°:  -41.4kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22453(2-(cyclohexylamino)-5-methyl-5-propyl-4,5-dihydro-...)
Affinity DataKi:  55nM ΔG°:  -41.0kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22460(5-ethyl-5-methyl-2-[(2,2,3,3-tetramethylcyclopropy...)
Affinity DataKi:  58nM ΔG°:  -40.9kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22454(2-[(cyclohexylmethyl)amino]-5-ethyl-5-methyl-4,5-d...)
Affinity DataKi:  64nM ΔG°:  -40.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22462(2-{bicyclo[2.2.1]heptan-1-ylamino}-5-ethyl-5-methy...)
Affinity DataKi:  73nM ΔG°:  -40.3kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22456(2-(cycloheptylamino)-5-ethyl-5-methyl-4,5-dihydro-...)
Affinity DataKi:  82nM ΔG°:  -40.0kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22451(2-(cyclohexylamino)-5-ethyl-5-methyl-4,5-dihydro-1...)
Affinity DataKi:  126nM ΔG°:  -39.0kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22465(2-{bicyclo[2.2.1]heptan-7-ylamino}-5-methyl-5-prop...)
Affinity DataKi:  149nM ΔG°:  -38.6kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Affinity DataKi:  180nM ΔG°:  -38.1kJ/molepH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22464(2-{bicyclo[2.2.1]heptan-7-ylamino}-5-ethyl-5-methy...)
Affinity DataKi:  372nM ΔG°:  -36.3kJ/molepH: 7.2 T: 2°CAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22473(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22456(2-(cycloheptylamino)-5-ethyl-5-methyl-4,5-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22457(2-(cycloheptylamino)-5-methyl-5-propyl-4,5-dihydro...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22458(2-(cyclooctylamino)-5-ethyl-5-methyl-4,5-dihydro-1...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22459(2-(cyclooctylamino)-5-methyl-5-propyl-4,5-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22462(2-{bicyclo[2.2.1]heptan-1-ylamino}-5-ethyl-5-methy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22465(2-{bicyclo[2.2.1]heptan-7-ylamino}-5-methyl-5-prop...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22466(5-ethyl-5-methyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22470(2-(cyclooctylamino)-5,5-diethyl-4,5-dihydro-1,3-th...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22471(2-(cyclooctylamino)-1-thia-3-azaspiro[4.4]non-2-en...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed
LigandPNGBDBM22472(5,5-diethyl-2-{tricyclo[3.3.1.0^{3,7}]nonan-3-ylam...)
Affinity DataIC50: 1.00E+4nMAssay Description:The 11beta-HSD1 enzyme assay was carried out in the replica plates of the compounds in reaction buffer containing substrate mixture [3H]-cortisone/NA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2008
Entry Details Article
PubMed