16 articles for thisTarget
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2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 12. 1,2-Dihydroquinolylmethyl analogues with high activity and specificity for bacterial dihydrofolate reductase.
Wellcome Research Laboratories
Selective inhibitors of monoamine oxidase. 4. SAR of tricyclic N-methylcarboxamides and congeners binding at the tricyclics' hydrophilic binding site.
Wellcome Research Laboratories
Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses.
Wellcome Research Laboratories
Effects of the indolocarbazole 3744W on the tyrosine kinase activity of the cytoplasmic domain of the platelet-derived growth factor beta-receptor.
Wellcome Research Laboratories
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Wellcome Research Laboratories
Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.
Wellcome Research Laboratories
Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones.
Wellcome Research Laboratories
Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some sulfonamidobenzoylglutamate and related derivatives.
Wellcome Research Laboratories
Benzo[f]quinazoline inhibitors of thymidylate synthase: methyleneamino-linked aroylglutamate derivatives.
Wellcome Research Laboratories
Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid.
Wellcome Research Laboratories
Development of a novel series of trialkoxyaryl derivatives as specific and competitive antagonists of platelet activating factor.
Wellcome Research Laboratories
Computer-aided design and synthesis of 5-substituted tryptamines and their pharmacology at the 5-HT1D receptor: discovery of compounds with potential anti-migraine properties.
Wellcome Research Laboratories
Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.
Wellcome Research Laboratories
2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms.
Wellcome Research Laboratories
Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid.
Wellcome Research Laboratories