BDBM14434 6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one::6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one::R-115777::R-115777 | Zarnestra::Racemic mixture::Tipifarnib::Zarnestra

SMILES Cn1cncc1[C@@](c2ccc(cc2)Cl)(c3ccc4c(c3)C(=CC(=O)N4C)c5cccc(c5)Cl)N

InChI Key InChIKey=PLHJCIYEEKOWNM-UHFFFAOYSA-N

Data  7 IC50  1 Other

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14434   

TargetATP-dependent RNA helicase RhlE(Vibrio fischeri (strain ATCC 700601 / ES114))
University of Washington At Seattle

LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 17nMAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2007
Entry Details Article
PubMed
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 7.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.860nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DatapH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of GGTase-1 in vitro using purified human enzyme to catalyze the reaction between [3H] GGPP and a biotinylated pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2007
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)