BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.1M data for 1.3M Compounds and 9.6K Targets. Of those, 1.5M data for 708K Compounds and 4.7K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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To help with training and testing AI and other models, BindingDB downloads and search results now provide the publication date and BindingDB curation date of each measurement.

38 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Flavones. 2. Synthesis and structure-activity relationship of flavodilol and its analogues, a novel class of antihypertensive agents with catecholamine depleting properties.EBI
Pennwalt
Carbostyril derivatives having potent beta-adrenergic agonist properties.EBI
TBA
Flavones. 1. Synthesis and antihypertensive activity of (3-phenylflavonoxy)propanolamines without beta-adrenoceptor antagonism.EBI
TBA
Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds.EBI
TBA
Affinity labels for beta-adrenoceptors: preparation and properties of alkylating beta-blockers derived from indole.EBI
TBA
6,7-Dichloro-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline . A structurally novel beta-adrenergic receptor blocking agent.EBI
TBA
Alkylating beta-blockers: activity of isomeric bromoacetyl alprenolol menthanes.EBI
TBA
Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.EBI
TBA
Synthesis and adrenoceptor affinity of some highly polar beta-substituted catecholamines.EBI
TBA
beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.EBI
TBA
Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.EBI
TBA
Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.EBI
Nippon Roche Research Center
Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI
Pfizer
Syntheses of 2,5- and 2,6-difluoronorepinephrine, 2,5-difluoroepinephrine, and 2,6-difluorophenylephrine: effect of disubstitution with fluorine on adrenergic activity.EBI
National Institute of Diabetes and Digestive and Kidney Diseases
SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI
Searle Research and Development
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI
Bristol-Myers Squibb
Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.EBI
Berlex Laboratories
Design and synthesis of propranolol analogues as serotonergic agents.EBI
Virginia Commonwealth University
Syntheses and adrenergic activities of ring-fluorinated epinephrines.EBI
National Institute of Diabetes
Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.EBI
TBA
 
Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamidesEBI
TBA
 
SYNTHESIS AND BIOLOGICAL EVALUATION OF A FLUORINATED ANALOG OF THE β-ADRENERGIC BLOCKING AGENT, METOPROLOLEBI
TBA
 
The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)EBI
TBA
 
The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.EBI
TBA
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI
Predix Pharmaceuticals
Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.EBI
Pfizer
4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor.EBI
Wyeth-Ayerst Research
(S)-N-tert-butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide [(S)-WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.EBI
Wyeth Research (Uk)
Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.EBI
Mayo Foundation
3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity.EBI
Eli Lilly
Nondepressant beta-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols.EBI
TBA
Synthesis and biological properties of 2-, 5-, and 6-fluoronorepinephrines.EBI
TBA
Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI
Solvay Duphar
A novel series of 2,5-substituted tryptamine derivatives as vascular 5HT1B/1D receptor antagonists.EBI
Monash University
In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI
TBA
Effect of fluorine substitution on the adrenergic properties of 3-(tert-butylamino)-1-(3,4-dihydroxyphenoxy)-2-propanol.EBI
National Institute of Diabetes
Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity.EBI
Virginia Commonwealth University