65 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution.
University of Athens
Multitarget drug discovery for tuberculosis and other infectious diseases.
University of Illinois At Urbana-Champaign
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
University of Athens
New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.
University of Athens
Head-to-head prenyl tranferases: anti-infective drug targets.
University of Illinois At Urbana-Champaign
Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives.
Instituto De Parasitolog£A Y Biomedicina&Quot;L£Pez-Neyra
Isoprenyl phosphinylformates: new inhibitors of squalene synthetase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Synthesis and biological activity of J-104,118, a novel, potent inhibitor of squalene synthase
TBA
Aromatic isosteres as conformational probes for an isoprenyl subunit: application to inhibitors of squalene synthase
TBA
The squalestatins: potent inhibitors of squalene synthase. The role of the tricarboxylic acid moiety.
TBA
Synthesis and squalene synthetase inhibitory activity of tripotassium 1-methyl-1-[(N-benzyl-N-farnesyl)aminoethylphosphinato]ethylphosphonate as a tethered analog of N-benzyl-N-farnesylamine-inorganic pyrophosphate ion pair
TBA
Novel benzoxazine and benzothiazine derivatives as multifunctional antihyperlipidemic agents.
University of Athens
Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: novel, highly potent and orally efficacious squalene synthase inhibitors.
Daiichi Sankyo
Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors.
Bayer Pharma
Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors.
Bayer Pharma
Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors.
Daiichi Sankyo
Design of more potent squalene synthase inhibitors with multiple activities.
University of Athens
Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
University of Turin
Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus.
University of Illinois At Urbana-Champaign
Zaragozic Acids D and D2: Potent Inhibitors of Squalene Synthase and of Ras Farnesyl-Protein Transferase
TBA
Synthesis of triphosphonate analogues of farnesyl pyrophosphate. Inhibitors of squalene synthase and protein:farnesyl transferase
TBA
J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs
TBA
Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine
TBA
Inhibition of farnesyl protein transferase by new farnesyl phosphonate derivatives of phenylalanine
TBA
Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B
TBA
Synthesis of novel monocyclic squalestatin analogues as potential inhibitors of squalene synthase
TBA
Semi-synthetic qualestatins: Squalene synthase inhibition and antifungal activity. The SAR of C6 and C7 modifications
TBA
The squalestatins: novel inhibitors of squalene synthase. The optimal C1 chain-length requirements.
TBA
Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
University of Illinois At Urbana-Champaign
Lipid-lowering (hetero)aromatic tetrahydro-1,4-oxazine derivatives with antioxidant and squalene synthase inhibitory activity.
University of Athens
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Johann Wolfgang Goethe University
Discovery of Novel 11-Membered Templates as Squalene Synthase Inhibitors.
Daiichi Sankyo RD Novare Co., Ltd.
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
Instituto Venezolano De Investigaciones CientíFicas
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo.
University of Illinois At Urbana-Champaign
Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.
Takeda Chemical Industries
Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles.
Zeneca Pharmaceuticals
Cyclopentanedi- and tricarboxylic acids as squalene synthase inhibitors: syntheses and evaluation.
Abbott Laboratories
(1 alpha, 2 beta, 3 beta, 4 alpha)-1,2-bis[N-propyl-N-(4-phenoxybenzyl) amino]carbonyl]cyclobutane-3,4-dicarboxylic acid (A-87049): a novel potent squalene synthase inhibitor.
Abbott Laboratories
Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives.
University of Athens
Synthesis and activity of a novel series of 3-biarylquinuclidine squalene synthase inhibitors.
Zeneca Pharmaceuticals
The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues.
Glaxo Wellcome Research and Development
alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Bristol-Myers Squibb Pharmaceutical Research Institute
Amidinium cation as a mimic of allylic carbocation: synthesis and squalene synthetase inhibitory activity of an amidinium analog of a carbocation intermediate.
Sandoz Research Institute
N-(arylalkyl)farnesylamines: new potent squalene synthetase inhibitors.
Sandoz Research Institute
Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Merck Research Laboratories
The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues.
Glaxo Research and Development
The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality.
Glaxo Research and Development
1,1-Bisphosphonate squalene synthase inhibitors: interplay between the isoprenoid subunit and the diphosphate surrogate.
Bristol-Myers Squibb Pharmaceutical Research Institute
Phenoxypropylamines: a new series of squalene synthase inhibitors.
Zeneca Pharmaceuticals