60 articles for thisTarget
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Article Title
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Discovery of novel amidobenzimidazole derivatives as orally available small molecule modulators of stimulator of interferon genes for cancer immunotherapy.
Korea Research Institute of Chemical Technology
Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences
Design and Assessment of First-Generation Heterobifunctional PPARĪ±/STING Modulators.
University of Minnesota
Non-kinase off-target inhibitory activities of clinically-relevant kinase inhibitors.
Purdue University
Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research.
Bristol-Myers Squibb Company
PDE-stable 2'3'-cGAMP analogues, containing 5'-S-phosphorothioester linkage, as STING agonists.
Purdue University
Macrocyclization strategy for improving candidate profiles in medicinal chemistry.
Gachon University
Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors.
National Health Research Institutes
Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.
China Pharmaceutical University
Discovery and Optimization of a STING Agonist Platform for Application in Antibody Drug Conjugates.
Mersana Therapeutics
S-acylthioalkyl ester (SATE)-based prodrugs of deoxyribose cyclic dinucleotides (dCDNs) as the STING agonist for antitumor immunotherapy.
Nankai University
Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer.
Boehringer Ingelheim Pharma
Structure-activity relationship study of amidobenzimidazole derivatives as stimulator of interferon genes (STING) agonists.
Peking Union Medical College
A comprehensive review on acridone based derivatives as future anti-cancer agents and their structure activity relationships.
Svkm'S Nmims
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
Fudan University
Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.
Korea Institute of Science and Technology
If small molecules immunotherapy comes, can the prime be far behind?
Zhejiang University
Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.
China Pharmaceutical University
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Southern Medical University
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Merck
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Korea Research Institute of Chemical Technology
Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.
China Pharmaceutical University
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists.
Shanghai Jiao Tong University
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Czech Academy of Sciences
Small molecule approaches to treat autoimmune and inflammatory diseases (Part II): Nucleic acid sensing antagonists and inhibitors.
Roche Innovation Center Shanghai
STING, a promising target for small molecular immune modulator: A review.
China Pharmaceutical University
Discovery of Non-Nucleotide Small-Molecule STING Agonists
Bristol Myers Squibb Research and Development
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
Takeda Pharmaceuticals International
Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences
Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists.
Chinese Academy of Sciences
Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING).
Invivogen
Targeting Stimulator of Interferon Genes (STING) for the Potential Treatment of Cancer and Infectious Diseases.
Usona Institute
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants.
Nankai University
Novel Compounds as STING Modulators for Treating Hepatitis B Virus Infections.
Smith, Gambrell & Russell
Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes.
Therachem Research Medilab
Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective.
China Pharmaceutical University
Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences and Gilead Sciences Research Centre At Iocb
Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
Peking Union Medical College
COMPOSITION AND METHOD FOR TREATMENT OF GRAM NEGATIVE BACTERIAL INFECTION
The State University of New York
Pyridopyrimidine derivative, preparation method therefor and medical use thereof
Jiangsu Hengrui Medicine Co.
PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUNDS AS KRAS INHIBITOR
Shanghai Kechow Pharma
NAPHTHYRIDINE AND PYRIDO[3,4-c]PYRIDAZINE DERIVATIVES AS GABAA ALPHA 5 RECEPTOR MODULATORS
Richter Gedeon
QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
Repare Therapeutics
Enhancing CD8+ T cells for adoptive T cell therapy by inhibiting PTPN1 (PTP1B) and PTPN2 (TC-PTP)
The Royal Institution For The Advancement of Learning/Mcgill University
Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, Rasopathies, and fibrotic disease
Shy Therapeutics
Compounds and methods useful in the treatment of a PRMT5-mediated disorder
Argonaut Therapeutics